Reverse Engineering Indigenous Wisdom
Issue 01 — Traditional Medical Systems
Reverse Engineering Indigenous Wisdom
What the West Buried, and What the Research Shows Now
- Author
- Temilola Grace Adedipe
- Training
- BS, Biomedical Engineering · ND and MScGH candidate
- Published
- October 2026
- Length
- 14 min · 38 references

Key points
- Question
- To what extent has contemporary research substantiated the botanical knowledge of indigenous and traditional medicine practitioners, and why has so much of it been dismissed rather than rigorously studied?
- Findings
- Frequently, at the preclinical level (in cell and animal studies). Compounds from Epimedium spp. (horny goat weed), Panax spp. (ginseng), and Centella asiatica (gotu kola) show osteogenic (bone-building), angiogenic (blood vessel–forming), and wound-healing activity in cell and animal models, and a fourth-century Chinese text led to artemisinin, which is now first-line therapy for uncomplicated falciparum malaria, although partial resistance to it has now been confirmed in Southeast Asia and East Africa. Clinical evidence for most of these agents remains limited, and crude plant preparations are not pharmacologically equivalent to purified compounds (i.e., a tea or powder made from the whole plant is not the same as compounds in the plant being extracted, purified, and dosed in the lab). Where rigorous trials have been done, some remedies have failed, among them Echinacea angustifolia (purple coneflower) for the common cold. Historical and legal records show that many of these traditions were excluded from Western medicine by statute and accreditation policy, not by evidence.
- Meaning
- Traditional knowledge is a productive source of research hypotheses, not a substitute for testing them. Where its evidence base is thin, that often reflects a history of exclusion rather than a record of failure, and it warrants rigorous, adequately funded study.
In plain language
Healers in many cultures used plants for the same problems scientists are working on today. In the lab, several of those plants contain compounds that help rebuild bone, skin, and blood vessels, and one led to a malaria drug whose discovery won the 2015 Nobel Prize in Physiology or Medicine. Most have not been tested well in people yet, one well-known cold remedy failed a careful trial, and some carry real risks, so nothing here is a reason to start taking an herb on your own.
Before you try anything in this article, read the safety notes
Someone Got There First
In 2019, as a senior in biomedical engineering, I was part of a team handed a clinical case by a medical innovation company. A 48-year-old man with Meyerding grade III spondylolisthesis (one vertebra had slipped forward 50% to 75% of the way over the one below it) and disc degeneration at L4–L5. Symptomatic high-grade slips like his are generally managed surgically, and the established techniques are built around spinal fusion (permanently joining the vertebrae so the segment stops moving).1,2Evidence: systematic review Our task was to design a regenerative alternative, an approach that might help the body rebuild instead. We built on a 2016 design from the École Polytechnique Fédérale de Lausanne, a poly(ethylene glycol) dimethacrylate hydrogel reinforced with nanofibrillated cellulose (a water-swollen polymer network strengthened with microscopic cellulose fibers), which restored disc height in cow intervertebral discs and held it through half a million loading cycles.3Evidence: ex vivo organ model Our biocompatible scaffold was designed to be implanted surgically through a minimally invasive approach with a dedicated implantation tool, and it was functionalized with growth factors (signaling proteins that direct cells to build new tissue) chosen for two different jobs. Transforming growth factor beta 1 (TGF-β1) and growth differentiation factor 5 (GDF-5) were meant to support regeneration of the nucleus pulposus (the gel-like core of the disc). On both edges, where the scaffold met the vertebrae, we added recombinant human bone morphogenetic protein 2 (rhBMP-2), a bone-building protein the US Food and Drug Administration approved in 2002 for a specific lumbar fusion procedure, to promote osteogenesis (new bone formation). Its use in spine surgery has since grown well beyond that approval, alongside reports of complications such as radiculitis (inflamed nerve roots) and bone forming where it should not.4 We spent a semester on the materials chemistry and 3D printed prototypes. Our design won the class competition.
A few years later, I found literature that had research groups loading icariin, a prenylated flavonol glycoside (a plant-derived compound) from Epimedium spp. (horny goat weed), into scaffolds strikingly similar to ours, including 3D-printed polycaprolactone and nano-hydroxyapatite constructs (frameworks made of a biodegradable plastic and a synthetic bone mineral) and calcium phosphate cements designed for bone repair.5 Icariin-loaded hydrogels have also driven chondrogenic differentiation (stem cells maturing into cartilage cells) of bone marrow mesenchymal stem cells (stem cells that can become bone, cartilage, or fat) and reduced cartilage degeneration in a rat model of osteoarthritis.6 In Chinese medicine, Epimedium has been recorded since the Shennong Bencao Jing, the earliest surviving Chinese materia medica (reference text of medicinal substances), compiled during the Eastern Han dynasty (25–220 CE),7 as an herb that tonifies the kidney (a functional organ system in Chinese medicine, not the anatomical kidney) and strengthens yang,8 and the Ming dynasty Compendium of Materia Medica describes it as able to “strengthen bones and muscles.”5 I thought I was working at the frontier of regenerative medicine. Instead, I was walking a path already paved.
Recognition, however, is not proof, and the evidence deserves to be stated plainly, because that is the standard of this publication. The mechanistic literature on icariin is overwhelmingly preclinical (cell culture and animal studies), and its toxicology has not been thoroughly characterized.5,6Evidence: animal and in vitro The strongest human data I found come from a single 24-month randomized, double-blind, placebo-controlled trial in 100 late-postmenopausal women with low bone mineral density, T-scores between −2.0 and −2.5 (the osteopenic range, below normal but above osteoporosis).9 Participants received Epimedium-derived phytoestrogen flavonoids (plant compounds that weakly mimic estrogen) or placebo, with 300 mg of calcium daily in both arms. Lumbar spine bone mineral density (bone density in the lower back) was preserved in the treatment group (+1.3% from baseline) while the placebo group lost 2.4%, and femoral neck density (the top of the thigh bone, near the hip) showed the same pattern (+1.6% versus −1.8%), with statistically significant differences between the groups at both sites (P = .006 and P = .008, meaning the gap is unlikely to be due to chance). Serum estradiol (the body’s main form of estrogen) and endometrial thickness (the lining of the uterus, which estrogen-like compounds can thicken) did not change.9Evidence: randomized controlled trial
Taken together, that is a meaningful signal. It is also one trial, in one population, of modest size, with 85 of 100 participants completing it. A single trial of this kind justifies replication, not a treatment recommendation. Equally important, Epimedium is not without risk. China’s National Medical Products Administration reported hepatotoxicity (liver injury) associated with Epimedium-containing preparations in 2008 and 2016, a 13-week rat study found hepatic and adrenal toxicity (damage to the liver and adrenal glands) without an identifiable no-observed-adverse-effect level (the highest dose that causes no detectable harm), and a safe clinical dose has not been established.8Evidence: narrative review
A Theory of the Body, Before the Microscope
Yet the plant was never the most impressive part of this story. What impresses me more is that the people who reached for it were already working from a model of how the body maintains itself.
My grandfather’s tradition, ìwòsàn ìbílẹ̀ (Yoruba for traditional healing: the practice of using herbs, roots, leaves, animal parts, and spiritual and cultural methods to treat illness and maintain health), describes kòkòrò, minute living organisms that reside in small sacs within the body. In equilibrium, they support digestion and reproduction. In excess, they cause disease, and the practitioner’s task is to reduce them, typically with bitter botanical preparations.10Evidence: documented traditional use It is a model of disease built without microscopes or germ theory. I am not claiming the Yoruba discovered bacteria, because they did not. I am claiming they conceptualized the body as an ecosystem that must be kept in balance. Biomedicine has arrived at a similar understanding along its own path, from Élie Metchnikoff’s early 20th-century theory that intestinal bacteria shape health and aging11 to the study of the human microbiome (the community of microorganisms living in and on the body), which the Human Microbiome Project began mapping systematically in 2007.12
On the other side of the world, Chinese medicine was codifying a parallel model in text. The Huangdi Neijing frames health as a dynamic equilibrium between the individual, the seasons, and the emotions, and it ranks the physician who prevents disease above the one who treats it once established, an early articulation of what we now call primary prevention (stopping disease before it starts).13Evidence: documented traditional use Ìwòsàn ìbílẹ̀, by contrast, had no single canonical text. It was transmitted orally, through Ifá verses and apprenticeship to practitioners, yet it converged on a comparable model, health as equilibrium between a person, their spirit, and their community, animated by a force the Yoruba call àṣẹ.
I was three when my family left Nigeria, and I remember little of Akure. Almost everything I know of my grandfather’s medicine reached me the way it reached him, spoken aloud, through my parents.
To be clear, qi and àṣẹ are not equivalent constructs, and I will not flatten them into one. They emerged from different cosmologies (worldviews about how life and the universe are ordered). Still, I was not prepared for how familiar China would feel. During clinical observation this summer at Beijing University of Chinese Medicine and Inner Mongolia Medical University, practitioners returned again and again to one principle, that health begins in daily habits, not in the clinic. Every morning on the walk to the hospital, grandparents were out at the badminton courts with their grandchildren, beside public exercise equipment open to anyone.
Early Leads From the Laboratory
Plants have also made their way into my first field, tissue engineering, and some of the most promising are ones that healers reached for first. Ginsenoside Rg1, a triterpenoid saponin (a soap-like plant compound) from Panax spp. (ginseng),14 is proangiogenic (it promotes the growth of new blood vessels). In vitro, it increased endothelial proliferation, invasion, and tube formation through nitric oxide synthase and PI3K–Akt signaling (chemical relay pathways that instruct cells to grow and move), and in vivo (in a living animal) it drove functional neovascularization (the formation of working new blood vessels) into an implanted polymer scaffold, while its structural relative Rb1 inhibited the earliest step of the process.15Evidence: animal and in vitro It is important to note that the ratio of Rg1 to Rb1 differs among Panax species, which suggests that not all ginseng behaves alike.15
Centella asiatica (gotu kola), long used in traditional wound care, has progressed further, into human trials. A 2022 systematic review identified four controlled trials. They studied oral asiaticoside in 170 patients with diabetic wounds, a topical preparation compared with silver sulfadiazine in 75 patients with partial-thickness burns, oral and topical Centella in 98 patients with chronic anal fissures, and a topical extract after laser resurfacing in 30 patients. Across them, Centella was associated with faster wound contraction, better granulation (new tissue filling the wound bed) and re-epithelialization (skin regrowing over the wound), and less pain and redness.16Evidence: systematic review
For me, this is the most exhilarating part of the work. Several promising leads in regenerative medicine come from plants that traditional medicine practitioners reached for first.5,15,16 Even so, scale matters. Most of this evidence is preclinical, and four heterogeneous trials (different products, populations, and outcomes) generate a hypothesis, not a verdict.
| Plant | Traditional use | Compound studied | Strongest evidence so far | Study type |
|---|---|---|---|---|
| Epimedium Epimedium spp. | Chinese medicine, recorded as able to “strengthen bones and muscles”5 | Icariin and related flavonoids | Bone density held steady over 24 months versus loss on placebo, in postmenopausal women. Studied daily: 60 mg icariin, 15 mg daidzein, 3 mg genistein9 | One RCT |
| Ginseng Panax spp. | Chinese medicine15 | Ginsenoside Rg1 | New blood vessel growth in cells and an implanted scaffold model15 | Animal and in vitro |
| Gotu kola Centella asiatica | Wound care in traditional medicine16 | Asiaticoside and whole extracts | Faster healing and better wound appearance in four small trials16 | Systematic review |
| Sweet wormwood Artemisia annua | Fevers, in a fourth-century Chinese handbook17 | Artemisinin | Artemisinin-based combination therapy is first-line malaria treatment.18 The raw plant is not supported.19 | WHO guideline |
Wring It Cold
If regenerative medicine shows this convergence in progress, malaria shows it complete. The clearest case of two knowledge systems meeting belongs to Tu Youyou. Screening traditional remedies for antimalarial activity, her team returned repeatedly to Artemisia annua (sweet wormwood, known in Chinese as qinghao), but its extracts performed inconsistently and failed to reproduce in the laboratory. The breakthrough came from a fourth-century text, Ge Hong’s Handbook of Prescriptions for Emergencies. “A handful of qinghao immersed with 2 liters of water, wring out the juice and drink it all.”17
Read closely, the instruction suggested that heat, routine in conventional extraction, might be degrading the active constituent. Tu’s team moved to a lower-temperature extraction, and on October 4, 1971, they obtained a nontoxic, neutral extract that was 100% effective against parasitemia (malaria parasites in the blood) in infected mice and monkeys.17 That work yielded artemisinin, and in 2015 Tu shared the Nobel Prize in Physiology or Medicine.20 Artemisinin-based combination therapies are now the World Health Organization’s recommended treatment for uncomplicated Plasmodium falciparum malaria.18Evidence: clinical guideline
Yet the story carries an equally important caution. The WHO does not support Artemisia plant material in any form, including teas and dried leaf, for the prevention or treatment of malaria. Artemisinin content in the plant varies widely, the doses delivered are often subtherapeutic (too low to clear the infection), and widespread use could accelerate artemisinin resistance.19Evidence: WHO position statement That concern is no longer hypothetical. Artemisinin partial resistance (a delay in how quickly the drug clears parasites from the blood) is established in the Greater Mekong Subregion of Southeast Asia and has now been confirmed in Eritrea, Rwanda, Uganda, and Tanzania. Combination therapies remain the best available treatment, but where resistance to their partner drugs has also emerged, as in parts of Southeast Asia, several are failing.21Evidence: WHO surveillance The manuscript pointed the way. The laboratory turned it into a medicine.
The manuscript knew something the laboratory could not have guessed.The laboratory proved something the manuscript could only claim.
What the Law Buried
None of this would have been possible had the manuscripts been lost. Tu could consult them because they had been preserved. Over the twentieth century, China chose to institutionalize its traditional medicine within the modern hospital system, funding it, teaching it, and debating it openly, and in 2016 it enacted a national law recognizing traditional Chinese medicine as an important part of the country’s health system.22 I saw that policy translated into infrastructure. Herbal pharmacies in residential neighborhoods. A full decoction facility inside a Beijing hospital, compounding individualized formulas at scale. The model is still contested, and a living tradition earns real criticism. But the choice was deliberate.
This is not a marginal question for global health. In the WHO’s 2019 global report on traditional and complementary medicine, 88% of its member states acknowledged that these practices are used in their countries.23 Much of the West, however, made the opposite choice, and frequently it made that choice by law.
The pattern begins close to home, in the profession I am training in. After the 1910 Flexner Report standardized American medical education around a single biomedical model, schools teaching homeopathic, eclectic, and botanical medicine were pressured to abandon that curriculum or lose accreditation and funding, and most complied or closed.24,25 The same report deemed only two of the seven historically Black medical schools, Howard and Meharry, worth developing.26 A 2020 economic evaluation estimated that five of the Black medical schools that closed would have trained an additional 27,773 to 35,315 graduates by 2019 had they remained open.27
The roots of that exclusion run deeper still. In 1748, colonial Virginia made it a capital offense for an enslaved person to administer “any medicine whatsoever,” with narrow exceptions that required the enslaver’s permission.28 In 1751, South Carolina barred enslaved healers from administering any medicine unless a white person directed it.29 People who carried botanical knowledge across an ocean were criminalized for using it.
Across the Atlantic, in colonial Nigeria, missionaries and colonial authorities classified Yoruba healing as superstitious and harmful. Beginning with the Criminal Code of 1916, the colonial government enacted legislation to suppress it and redirect people toward Western medicine.30 Meanwhile, in the United States, the 1883 rules for the Courts of Indian Offenses made the practices of Native medicine people an offense punishable by at least ten days in the agency jail, and they penalized certain ceremonies by withholding rations.31 Not until 1934 did a federal circular question those bans,32 and not until 1978 did Congress pass the American Indian Religious Freedom Act.33
Taken together, consider who appears on this list. Yoruba medicine. The plant knowledge of enslaved Africans. Native healing. Botanical medicine, including the plant knowledge within the naturopathic tradition I am studying. My claim here concerns that botanical knowledge, not every therapy taught under the naturopathic name. For many, the testing never happened. They were removed by statute before they could be rigorously studied.
Where the Evidence Stops
None of this history, however, is a license to overstate the science. In keeping with this publication’s standard, here is where the evidence holds and where it does not.
- Most of the regenerative findings discussed here are preclinical. They establish biological plausibility and mechanism, not clinical efficacy (proven benefit in patients).5,6,15
- The human evidence is limited. For Epimedium, it rests on one randomized trial in a single population of postmenopausal women.9 For Centella, it rests on four small, heterogeneous trials with different formulations and end points.16
- Documented traditional use and the conceptual parallels among kòkòrò, qi, and àṣẹ are hypothesis-generating. They cannot exclude confounding (other explanations, such as diet or natural recovery), and they are not evidence of efficacy.10,13
- Safety is part of the evidence. Epimedium carries documented hepatotoxicity signals,8 and nonpharmaceutical Artemisia (the plant itself, as tea, powder, or dried leaf) is not a substitute for artemisinin-based combination therapy.19
Some of this knowledge has been tested and has not held up. Echinacea angustifolia (purple coneflower) was among the most widely used medicinal plants of the Plains nations, taken for coughs, colds, and sore throats.34 In a 2005 randomized controlled trial (participants assigned by chance to an extract or a placebo), 399 volunteers were deliberately exposed to a common cold virus. Three different root extracts, taken either before exposure or starting at exposure, did not reduce infection rates or symptom severity compared with placebo.35Evidence: randomized controlled trial A tradition can point to the right question and still arrive at the wrong answer, and that result belongs here as much as artemisinin does.
What would resolve these questions, then, is not methodologically complicated, only underfunded. Adequately powered randomized trials (large enough to detect a real effect) of standardized, chemically characterized preparations, with prespecified safety monitoring. Community-engaged research conducted with the people who hold this knowledge rather than about them. And systematic documentation of oral traditions before more of them are lost.
Counting Knowledge as Knowledge
Ultimately, this is a question of whose knowledge counts. The philosopher Miranda Fricker calls it epistemic injustice when a person’s knowledge is discounted because of who they are.36 Indigenous and traditional medicine has lived under it for centuries. “There is no evidence” is often stated as though it were a finding. Frequently it reflects an absence of investigation, not evidence of absence. Often, the studies were never funded. Congress first funded an NIH office to study unconventional medical practices in 1991, and it did not become a full NIH center until 1998.37 When that center paid for a rigorous trial, as it did for the echinacea study above, it got an answer.38
The answer, however, is not to accept every remedy because it is old. That would be its own kind of disrespect, to the people who deserve real answers about what they put in their bodies. The answer is to take this knowledge seriously enough to test it. Ask the elder what she knows. Then run the trial. Report what holds up, what has never been studied or is understudied, and what does not work, and say all three out loud.
In the end, when those old laws were written, no one in the room had used the plants in question. We are the ones in the room now. Tu Youyou needed the manuscript and the laboratory. So do we.
Before you try this
- This article is education, not medical advice. Nothing here recommends a treatment, preparation, or dose for you.
- Talk with your primary care clinician, a pharmacist, or a licensed naturopathic doctor before starting any herb or supplement, especially if you are pregnant or breastfeeding, take prescription medications, or are managing a chronic condition.
- Preparations and amounts appear only as they were used in published studies. They are reported, not recommended.
- Epimedium spp. (horny goat weed). Liver injury linked to Epimedium preparations has been reported to China’s national drug regulator, and a safe dose has not been established.8
- Artemisia annua (sweet wormwood). The WHO does not support Artemisia teas, powders, or capsules to prevent or treat malaria. Malaria is a medical emergency. Get tested and treated.19
- Centella asiatica (gotu kola). The human trials used specific products, several of them applied to the skin. They are not instructions for home use.16
- Panax spp. (ginseng). The findings here come from cells and animals only. Ask a clinician or pharmacist about interactions before combining any herb with your medications.
References
- Passias PG, Poorman CE, Yang S, et al. Surgical treatment strategies for high-grade spondylolisthesis: a systematic review. Int J Spine Surg. 2015;9:50. doi:10.14444/2050
- Kunze KN, Lilly DT, Khan JM, et al. High-grade spondylolisthesis in adults: current concepts in evaluation and management. Int J Spine Surg. Published online June 2020. doi:10.14444/7044
- Schmocker A, Khoushabi A, Frauchiger DA, et al. A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement. Biomaterials. 2016;88:110-119. doi:10.1016/j.biomaterials.2016.02.015
- Bannwarth M, Smith JS, Bess S, et al. Use of rhBMP-2 for adult spinal deformity surgery: patterns of usage and changes over the past decade. Neurosurg Focus. 2021;50(6):E4. doi:10.3171/2021.3.FOCUS2164
- Seyedi Z, Amiri MS, Mohammadzadeh V, et al. Icariin: a promising natural product in biomedicine and tissue engineering. J Funct Biomater. 2023;14(1):44. doi:10.3390/jfb14010044
- Zhu Y, Ye L, Cai X, et al. Icariin-loaded hydrogel regulates bone marrow mesenchymal stem cell chondrogenic differentiation and promotes cartilage repair in osteoarthritis. Front Bioeng Biotechnol. 2022;10:755260. doi:10.3389/fbioe.2022.755260
- Zhao Z, Guo P, Brand E. A concise classification of bencao (materia medica). Chin Med. 2018;13:18. doi:10.1186/s13020-018-0176-y
- Cui J, Lin L, Hao F, et al. Comprehensive review of the traditional uses and the potential benefits of epimedium folium. Front Pharmacol. 2024;15:1415265. doi:10.3389/fphar.2024.1415265
- Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res. 2007;22(7):1072-1079. doi:10.1359/jbmr.070405 Original record.
- Buckley AD. Yoruba Medicine. Clarendon Press; 1985. Original record.
- Mackowiak PA. Recycling Metchnikoff: probiotics, the intestinal microbiome and the quest for long life. Front Public Health. 2013;1:52. doi:10.3389/fpubh.2013.00052
- Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The Human Microbiome Project. Nature. 2007;449(7164):804-810. doi:10.1038/nature06244 Original record.
- Ni M, trans. The Yellow Emperor’s Classic of Medicine: A New Translation of the Neijing Suwen With Commentary. Shambhala; 1995. Original record.
- Choi JS, Chun KS, Kundu J, Kundu JK. Biochemical basis of cancer chemoprevention and/or chemotherapy with ginsenosides (review). Int J Mol Med. 2013;32(6):1227-1238. doi:10.3892/ijmm.2013.1519
- Sengupta S, Toh SA, Sellers LA, et al. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004;110(10):1219-1225. doi:10.1161/01.CIR.0000140676.88412.CF Original record.
- Arribas-López E, Zand N, Ojo O, et al. A systematic review of the effect of Centella asiatica on wound healing. Int J Environ Res Public Health. 2022;19(6):3266. doi:10.3390/ijerph19063266
- Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10):1217-1220. doi:10.1038/nm.2471
- World Health Organization. WHO Guidelines for Malaria. World Health Organization; September 10, 2026. Accessed October 14, 2026. https://www.who.int/publications/i/item/guidelines-for-malaria
- World Health Organization. The Use of Non-Pharmaceutical Forms of Artemisia. World Health Organization; 2019. WHO/CDS/GMP/2019.14. https://www.who.int/news/item/10-10-2019-the-use-of-non-pharmaceutical-forms-of-artemisia
- The Nobel Prize in Physiology or Medicine 2015. NobelPrize.org. Accessed October 14, 2026. https://www.nobelprize.org/prizes/medicine/2015/summary/
- World Health Organization. Malaria: artemisinin partial resistance. Published January 9, 2025. Accessed October 15, 2026. https://www.who.int/news-room/q-a-detail/artemisinin-resistance
- National Health Commission of the People’s Republic of China. TCM law promotes healthy progress. December 26, 2016. Accessed October 14, 2026. https://en.nhc.gov.cn/2016-12/26/c_70933.htm
- World Health Organization. WHO Global Report on Traditional and Complementary Medicine 2019. World Health Organization; 2019. https://www.who.int/publications/i/item/978924151536
- Flexner A. Medical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of Teaching. Bulletin No. 4. Carnegie Foundation for the Advancement of Teaching; 1910. Original record.
- Stahnisch FW, Verhoef M. The Flexner Report of 1910 and its impact on complementary and alternative medicine and psychiatry in North America in the 20th century. Evid Based Complement Alternat Med. 2012;2012:647896. doi:10.1155/2012/647896
- Laws T. How should we respond to racist legacies in health professions education originating in the Flexner Report? AMA J Ethics. 2021;23(3):E271-275. doi:10.1001/amajethics.2021.271
- Campbell KM, Corral I, Infante Linares JL, Tumin D. Projected estimates of African American medical graduates of closed historically Black medical schools. JAMA Netw Open. 2020;3(8):e2015220. doi:10.1001/jamanetworkopen.2020.15220
- Thomas Jefferson Foundation. Slave medicine. Monticello exhibition archive. Accessed October 14, 2026. https://www.monticello.org/library/exhibits/lucymarks/medical/slavemedicine.html. Citing Blanton WB. Medicine in Virginia in the Eighteenth Century, p 174.
- Doctor Caesar and his antidote for poison in 1750. Charleston Time Machine. Charleston County Public Library. Accessed October 14, 2026. https://ccpl.org/charleston-time-machine/doctor-caesar-and-his-antidote-poison-1750
- Ige A. Medical Pluralism and Epistemic Contestations in Colonial Southwestern (Yoruba) Nigeria. Dissertation. University of Glasgow; 2026. https://theses.gla.ac.uk/85914/
- US Department of the Interior, Office of Indian Affairs. Rules Governing the Court of Indian Offenses. 1883. Original record.
- National Library of Medicine. Native Voices timeline, 1934 entry. Accessed October 14, 2026. https://www.nlm.nih.gov/nativevoices/timeline/453.html
- American Indian Religious Freedom Act, Pub L No. 95-341, 92 Stat 469 (1978). Original record.
- Kindscher K. Ethnobotany of purple coneflower (Echinacea angustifolia, Asteraceae) and other Echinacea species. Econ Bot. 1989;43(4):498-507. doi:10.1007/BF02935924 Original record.
- Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med. 2005;353(4):341-348. doi:10.1056/NEJMoa044441 Original record.
- Fricker M. Epistemic Injustice: Power and the Ethics of Knowing. Oxford University Press; 2007. Original record.
- National Institutes of Health. National Center for Complementary and Integrative Health (NCCIH). NIH Almanac. Accessed October 21, 2026. https://www.nih.gov/about-nih/nih-almanac/national-center-complementary-integrative-health-nccih
- National Center for Complementary and Alternative Medicine. Echinacea for the prevention and treatment of colds in adults: research results and implications for future studies. Archived May 5, 2009. Accessed October 22, 2026. https://webarchive.library.unt.edu/eot2008/20090505203423mp_/http:/nccam.nih.gov/research/results/echinacea_rr.htm
- Cite as
- Adedipe TG. Reverse engineering indigenous wisdom. The ÀWA Collective. Published October 2026. Accessed [date]. https://theawacollective.com/articles/reverse-engineering-indigenous-wisdomClick the citation once to select it, then copy. Replace [date] with the date you read this page.
- Disclosures
- The author is a naturopathic medical student and the founder of The ÀWA Collective. From 2021 to 2025 she operated the ÀWA Marketplace, which sold personal care products from Black-owned brands. The Collective no longer sells products, is self-funded, and accepts no advertising.
- Corrections
- Errors are corrected and noted here with the date of the change. To report one, use the Suggest a Topic form.
- Disclaimer
- This article is for education. It is not medical advice and is not a substitute for care from a licensed healthcare provider.

Temilola Grace Adedipe
Founder of The ÀWA Collective. Naturopathic medical student and Master of Science in Global Health candidate at the National University of Natural Medicine, with a BS in Biomedical Engineering from the University of Texas at San Antonio.
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